Pep Guardiola’s side has become synonymous with the competition since his landing in England, lifting the trophy on four separate occasions since 2018.
Dethroned last season, City looks favorites to win it again this time around. In fantastic form and with holders Liverpool and Premier League leaders Arsenal knocked out, it’d be brave to bet against them.
Saints, meanwhile, got their first win under new manager Nathan Jones against Crystal Palace in the FA Cup on Saturday but remain unconvincing.
The former Luton boss is yet to convince supporters, who were heard to have criticised his brand of football at Selhurst Park. Still, a shock win against City would be some way into building support.
The Carabao Cup quarter-final is scheduled for an 8pm GMT kick-off on Wednesday 11 January, 2023.
St Mary’s Stadium in Southampton will host.
Where to watch Southampton vs Manchester City
TV channel: In the UK, the match will be televised live on Sky Sports Football and Main Event, with coverage starting at 7.30 pm GMT for an 8 pm kick-off.
Live stream: Fans can also catch the game live online via the Sky go app.
Live blog: You can follow all the action on matchday via Standard Sport’s live blog.
Southampton vs Manchester City team news
Jones has confirmed Armel Bella-Kotchap and Stuart Armstrong will miss the game having missed the win over Palace.
New signing Mislav Orisic, meanwhile, could make his debut in at least some capacity though is unlikely to be rushed at this stage.
Guardiola has revealed Kalvin Phillips is in line to start on the south coast, while the City boss was able to rest the likes of Erling Haaland and Kevin De Bruyne for Sunday’s FA Cup win over Chelsea.
Given the importance the City boss has placed on this competition, it seems likely he will name the strongest starting lineup possible.
Southampton vs Manchester City prediction
While it’ll be fascinating to see if Jones can build on his first win, beating a City side likely to be at full strength is quite the ask even for a team in good form.
Manchester City is to win 2-0.
Southampton vs Manchester City head-to-head record
Southampton wins: 32
Manchester City wins: 40
Southampton vs Manchester City latest odds
(After 90 mins)
Southampton to win: 12/1
Manchester City to win: 1/5